abstract：:A role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated E...

journal_title：Epilepsy research

authors： Hidaka N,Suemaru K,Kato Y,Araki H

更新日期：2013-03-01 00:00:00

abstract：:To investigate involvement of extrafocal regions in mesial temporal lobe epilepsy (MTLE), we retrospectively explored abnormalities in distribution of iomazenil (IMZ) activity by identifying interhemispheric asymmetry on IMZ-SPECT images of patients with MTLE. Fourteen MTLE patients in whom a good surgical outcome was...

journal_title：Epilepsy research

authors： Hosomi K,Kishima H,Oshino S,Hirata M,Tani N,Maruo T,Khoo HM,Shimosegawa E,Hatazawa J,Kato A,Yoshimine T

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Treatment of paediatric epilepsy has advanced with the development of new antiepileptic drugs (AEDs). There are few data for Germany to which extent new AEDs are used in the treatment of childhood epilepsy. AIMS:To characterise utilisation of antiepileptics in children and adolescents with a specific emphas...

journal_title：Epilepsy research

authors： Dörks M,Langner I,Timmer A,Garbe E

更新日期：2013-01-01 00:00:00

abstract：:Generalized epilepsy with febrile seizures plus (GEFS+) comprises a group of clinically and genetically heterogeneous epilepsy syndrome. Here, we provide the first report of clinical presentation and mutational analysis of SCN1A gene in 36 Malaysian GEFS+ patients. Mutational analysis of SCN1A gene revealed twenty sev...

journal_title：Epilepsy research

authors： Tan EH,Razak SA,Abdullah JM,Mohamed Yusoff AA

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To clarify the clinical and neurophysiological profiles of fronto-parietal opercular epilepsy in which epileptic spikes are detected with magnetoencephalography (MEG) but not with scalp electroencephalography (EEG). METHODS:Four patients presented with epileptic spikes localized to the fronto-parietal opercu...

journal_title：Epilepsy research

authors： Kakisaka Y,Iwasaki M,Alexopoulos AV,Enatsu R,Jin K,Wang ZI,Mosher JC,Dubarry AS,Nair DR,Burgess RC

更新日期：2012-11-01 00:00:00

abstract：:Mutations of the neuronal voltage-gated sodium channel alpha subunit type II (SCN2A) cause various epileptic syndromes, but have never been reported in association with acute encephalopathy. To validate the involvement of SCN2A mutations in acute encephalopathy, we screened 25 patients and found a novel missense mutat...

journal_title：Epilepsy research

authors： Kobayashi K,Ohzono H,Shinohara M,Saitoh M,Ohmori I,Ohtsuka Y,Mizuguchi M

更新日期：2012-11-01 00:00:00

abstract：:To study the risk of developing unprovoked seizures among patients with multiple sclerosis (MS) and systemic lupus erythematosus (SLE), we used 1885 new onset seizure cases, 15,080 controls and defined exposure as a hospital discharge diagnosis of MS or SLE. The odds ratio with 95% confidence interval was 3.7 (CI 1.2-...

journal_title：Epilepsy research

authors： Adelöw C,Andersson T,Ahlbom A,Tomson T

更新日期：2012-09-01 00:00:00

abstract：:Resting motor threshold (rMT) assessed by means of Transcranial Magnetic Stimulation (TMS) is thought to reflect trans-synaptic excitability of cortico-spinal neurons. TMS studies reporting rMT in idiopathic generalized epilepsies (IGEs) yielded discrepant results, so that it is difficult to draw a definitive conclusi...

journal_title：Epilepsy research

authors： Brigo F,Storti M,Benedetti MD,Rossini F,Nardone R,Tezzon F,Fiaschi A,Bongiovanni LG,Manganotti P

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:We performed this study to evaluate the frequency, types, and ictal electroencephalography (EEG) findings of coexisting seizures in patients with infantile spasms at the onset of spasms. We also evaluated the effect of coexisting seizures on short-term seizure control. METHODS:We retrospectively reviewed the l...

journal_title：Epilepsy research

authors： Kim H,Lee JH,Ryu HW,Lim BC,Chae JH,Choi J,Kim KJ,Hwang YS,Hwang H

更新日期：2012-08-01 00:00:00

abstract：:The antidepressant drug fluoxetine (FLX) has been shown to exert antiepileptic effects in several animal models, but mixed preclinical findings and occasional reports of proconvulsant effects have led to hesitation towards its use in epileptic people. Despite being developed as a selective serotonin reuptake inhibitor...

journal_title：Epilepsy research

authors： Igelström KM,Heyward PM

更新日期：2012-08-01 00:00:00

abstract：:Multiple forms of the ketogenic diet (KD) have been successfully used to treat drug-resistant epilepsy, however its mainstream use as a first-line therapy is still limited. Further investigation into its clinical efficacy as well as the molecular basis of activity is likely to assist in the reversal of any resistance ...

journal_title：Epilepsy research

authors： Hallböök T,Ji S,Maudsley S,Martin B

更新日期：2012-07-01 00:00:00

abstract：:The present study examined whether the perceived behavioral problems of children with idiopathic epilepsy differed from those of healthy controls according to parent proxy-reports and which factors are associated with these problems. The parents of 106 children with idiopathic epilepsy and 305 healthy controls aged 6-...

journal_title：Epilepsy research

authors： Dafoulis V,Kalyva E

更新日期：2012-06-01 00:00:00

abstract：:Infantile spasms (IS) is a devastating epilepsy syndrome treated with adrenocorticotropic hormone (ACTH). To demonstrate the effects of adrenal dysfunction, adrenalectomy (ADX) and N-methyl-d-aspartate (NMDA)-induced rat model studies of IS were performed. The latency of the seizure in the ADX group decreased and the ...

journal_title：Epilepsy research

authors： Wang YJ,Zhang Y,Liang XH,Yang G,Zou LP

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to determine the histological effects of valproic acid (VPA) on the penis in prepubertal rats. METHODS:Twelve male Wistar rats (21-24 days old) were divided equally into 2 experimental groups, and given tap water (control group) or 300mg/kg/day VPA via gavage for 30 days. After t...

journal_title：Epilepsy research

authors： Kutlu O,Cansu A,Karagüzel E,Gürgen SG,Koç O,Gür M,Ozgür GK

更新日期：2012-05-01 00:00:00

abstract：:Triheptanoin, the triglyceride of heptanoate, is used to treat certain hereditary metabolic diseases in USA because of its anaplerotic potential. In two chronic mouse seizure models this clear tasteless oil was found to be reproducibly anticonvulsant. Here we investigated the effects of triheptanoin feeding in C3H and...

journal_title：Epilepsy research

authors： Thomas NK,Willis S,Sweetman L,Borges K

更新日期：2012-05-01 00:00:00

abstract：:Sodium valproate is a drug widely used for the treatment of epilepsy and mood disorders. We studied the effect of valproate on cerebral energy metabolism by incubating rat brain slices with 5 mM [3-(13)C]glutamate in the absence and the presence of 1 mM valproate. Substrate removal and product formation were measured ...

journal_title：Epilepsy research

authors： El Hage M,Baverel G,Martin G

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Recent analyses provided evidence that human adult cerebrospinal fluid (CSF) in addition to soluble proteins also contains membrane particles that moreover carry the somatic stem cell marker CD133. The significance of CD133 as a potential marker of cellular proliferation, including neurogenesis, remains unresol...

journal_title：Epilepsy research

authors： Huttner HB,Corbeil D,Thirmeyer C,Coras R,Köhrmann M,Mauer C,Kuramatsu JB,Kloska SP,Doerfler A,Weigel D,Klucken J,Winkler J,Pauli E,Schwab S,Hamer HM,Kasper BS

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Idiopathic epilepsy (IE) is a syndrome that comprises epilepsy only, with no underlying structural brain lesion or other neurological signs or symptoms. Numerous studies have shown that genetic factors play an important role in IE. IE is a common disease in the Chinese Han population. However, the genetic ep...

journal_title：Epilepsy research

authors： Li M,Heng X,Tao R,Liu J,Zhang L,Sun X,Wang L,Wu Q,Che F,Xue F

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To identify consistent results of voxel-based morphometry (VBM) studies in unilateral refractory temporal lobe epilepsy (TLE). METHODS:Whole-brain VBM studies comparing refractory TLE patients with healthy controls (HC) were systematically searched in PubMed, ISI Web of Science, Embase, and Medline databases f...

journal_title：Epilepsy research

authors： Li J,Zhang Z,Shang H

更新日期：2012-02-01 00:00:00

abstract：:We planned this study to investigate the frequency of epilepsy in paralytic polio survivors. We analyzed the clinical data of 91 paralytic polio survivors. Patients who had been diagnosed with epilepsy were examined by electroencephalography and brain magnetic resonance imaging. 11 of the 91 patients had epilepsy (12%...

journal_title：Epilepsy research

authors： Demir CF,Berilgen MS,Mungen B,Bulut S

更新日期：2012-01-01 00:00:00

abstract：:Seizures induced by the convulsant methionine sulfoximine (MSO) resemble human "grand mal" epilepsy, and brain glutamine synthetase is inhibited. We recently selected two inbred lines of mice: sensitive to MSO (MSO-Fast) and resistant (MSO-Slow). In the present study, the selection pressure was increased and consangui...

journal_title：Epilepsy research

authors： Boissonnet A,Hévor T,Cloix JF

更新日期：2012-01-01 00:00:00

abstract：:Photosensitive epilepsy (PSE) offers a highly reproducible model to investigate whether changes in neuronal activity preceding the transition to an epileptic photoparoxysmal response (PPR) may be detected. We investigated this possibility in patients with idiopathic PSE using MEG, as well as normal controls and non-ph...

journal_title：Epilepsy research

authors： Lopes da Silva FH,Harding GF

更新日期：2011-12-01 00:00:00

abstract：:The objective of the study was to explore clinical, electroencephalography (EEG), neuropsychological features and prognosis of myoclonic-astatic epilepsy (MAE). Of 327 children aged between 1 and 9 years with a diagnosis of generalized epilepsy followed between 2000 and 2008, 18 (5.5%) had MAE. Male significantly pred...

journal_title：Epilepsy research

authors： Trivisano M,Specchio N,Cappelletti S,Di Ciommo V,Claps D,Specchio LM,Vigevano F,Fusco L

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Activation of the neurokinin-1 (NK1) receptor by neuropeptide substance P (SP) induces and maintains epileptic activity in various experimental models of epilepsy. The primary objective of this study was to investigate whether neurobiological changes linked to NK1-SP receptor system are associated with hyperexc...

journal_title：Epilepsy research

authors： Danfors T,Åhs F,Appel L,Linnman C,Fredrikson M,Furmark T,Kumlien E

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:To improve the interpretability of figures containing an amplitude-integrated electroencephalogram (aEEG), we devised a color scale that allows us to incorporate spectral edge frequency (SEF) information into aEEG figures. Preliminary clinical assessment of this novel technique, which we call aEEG/SEF, was pe...

journal_title：Epilepsy research

authors： Kobayashi K,Mimaki N,Endoh F,Inoue T,Yoshinaga H,Ohtsuka Y

更新日期：2011-10-01 00:00:00

abstract：:In control rats, we examined the effects of ketogenic diet on NKCC1 and KCC2 expression levels in hippocampus. Neither the number of NKCC1 immunoreactive cells nor the intensity of labeling of KCC2 was found to modify in hippocampus of the rats after ketogenic diet treatment. These results indicate that ketogenic diet...

journal_title：Epilepsy research

authors： Gómez-Lira G,Mendoza-Torreblanca JG,Granados-Rojas L

更新日期：2011-09-01 00:00:00

abstract：:Here we describe a new non-human primate model of temporal lobe epilepsy (TLE) to better investigate the cause/effect relationships of human TLE. Status epilepticus (SE) was induced in adult marmosets by pilocarpine injection (250mg/kg; i.p.). The animals were divided in 2 groups: acute (8h post-SE) and chronic (3 and...

journal_title：Epilepsy research

authors： Perez-Mendes P,Blanco MM,Calcagnotto ME,Cinini SM,Bachiega J,Papoti D,Covolan L,Tannus A,Mello LE

更新日期：2011-09-01 00:00:00

abstract：:Simultaneous electroencephalography-transcranial magnetic stimulation (EEG-TMS) investigates cortical reactivity to external perturbations. TMS evoked potentials (TEPs) have been described in normals during sleep and wake but not after sleep deprivation or in pathologically enhanced excitability, i.e., epilepsy. The a...

journal_title：Epilepsy research

authors： Del Felice A,Fiaschi A,Bongiovanni GL,Savazzi S,Manganotti P

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:In patients with left temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS) decreased naming ability is common, suggesting a critical role for the medial left temporal lobe in this task. We investigated the integrity of language networks with functional MRI (fMRI) in controls and TLE patients. EXPERIM...

journal_title：Epilepsy research

authors： Bonelli SB,Powell R,Thompson PJ,Yogarajah M,Focke NK,Stretton J,Vollmar C,Symms MR,Price CJ,Duncan JS,Koepp MJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Many new antiepileptic drugs (AEDs) have become available in recent years. Investigations of prescription patterns and exposure of AEDs to different patient groups are important regarding drug safety aspects. The aim of this study was to investigate the use of AEDs in epilepsy, with focus on exposure of AEDs...

journal_title：Epilepsy research

authors： Landmark CJ,Fossmark H,Larsson PG,Rytter E,Johannessen SI

更新日期：2011-06-01 00:00:00

abstract：:Application of 4-aminopyridine (4-AP, 100μM) in a solution containing 0.6mM Mg(2+) and 1.2mM Ca(2+) to hippocampal-entorhinal-perirhinal slices of adult rat brain induced ictal-like epileptiform activity in entorhinal and perirhinal cortices as revealed by electrophysiological field potential recordings. The ictal-lik...

journal_title：Epilepsy research

authors： Salah A,Perkins KL

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:Indoleamine 2,3-dioxygenase (IDO) is a cytokine-inducible enzyme that participates in tryptophan (trp) and serotonin metabolism with an ability to modulate neuroinflammation. Several recent studies have shown associations between cytokines and epilepsy. In this study we investigated whether activation of IDO is...

journal_title：Epilepsy research

authors： Liimatainen S,Lehtimäki K,Raitala A,Peltola M,Oja SS,Peltola J,Hurme MA

更新日期：2011-05-01 00:00:00

abstract：:There is strong evidence that epileptic seizures occur in diurnal or 24-h patterns. A study in rat models of partial epilepsy showed circadian seizure patterns, and in humans circadian rhythmicity in interictal discharges has been found, suggesting that circadian rhythm may play a role in epilepsy. Circadian influence...

journal_title：Epilepsy research

authors： Hofstra WA,Gordijn MC,van der Palen J,van Regteren R,Grootemarsink BE,de Weerd AW

更新日期：2011-05-01 00:00:00

abstract：:The KCNAB1 gene is a candidate susceptibility factor for lateral temporal epilepsy (LTE) because of its functional interaction with LGI1, the gene responsible for the autosomal dominant form of LTE. We investigated association between polymorphic variants across the KCNAB1 gene and LTE. The allele and genotype frequen...

journal_title：Epilepsy research

authors： Busolin G,Malacrida S,Bisulli F,Striano P,Di Bonaventura C,Egeo G,Pasini E,Cianci V,Ferlazzo E,Bianchi A,Coppola G,Elia M,Mecarelli O,Gobbi G,Casellato S,Marchini M,Binelli S,Freri E,Granata T,Posar A,Parmeggiani

更新日期：2011-03-01 00:00:00

abstract：:Outbred rats are widely used in biomedical research studies. The genotypic variation, different housing and handling conditions during development, and gender of used rats can be expected to cause variations in behavior and epileptogenesis. We tested the hypothesis that adult female Wistar rats from different breeders...

journal_title：Epilepsy research

authors： Honndorf S,Lindemann C,Töllner K,Gernert M

更新日期：2011-03-01 00:00:00

abstract：:The objective of the study was to validate the Chinese version of The Liverpool Adverse Events Profile (LAEP) in patients with epilepsy. The scale was translated from the English version into a Chinese version and was then back-translated to examine its accuracy. Content validity, concurrent validity, and construct va...

journal_title：Epilepsy research

authors： Chen HF,Tsai YF,Shih MS,Chen JC

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:To analyze electroclinical features of absence seizures during sleep. PRINCIPAL RESULTS:30 children with genetic generalized epilepsy had 52 paroxysms of GSW >2s during sleep. 18/52 (35%) demonstrated a clinical sign. Ictal GSW lasted an average of 6.5s. CONCLUSION:Motor manifestations are seen during GSW>2s ...

journal_title：Epilepsy research

authors： Sadleir LG,Farrell K,Smith S,Connolly MB,Scheffer IE

更新日期：2011-02-01 00:00:00

abstract：:Although memory, language, and executive functions have been extensively studied in patients with mesial temporal lobe epilepsy (MTLE), few investigations of the decision-making abilities of these patients have been performed. We studied implicit decision-making (decisions under ambiguity) in right and left MTLE patie...

journal_title：Epilepsy research

authors： Yamano M,Akamatsu N,Tsuji S,Kobayakawa M,Kawamura M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:EEG monitoring is important for the early detection of seizures during the course of critical illness. However, the logistics of real time EEG interpretation is challenging for the neurophysiology and critical care medicine teams. This study evaluated factors affecting the utility of digital trend analysis (...

journal_title：Epilepsy research

authors： Akman CI,Micic V,Thompson A,Riviello JJ Jr

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:to determine how the duration of SE, the EEG findings during/after SE, the depth of coma at presentation and age impact on the prognosis of convulsive status epilepticus indepedent of aetiology and to analyse the outcome of status epilepticus with respect to mortality and morbidity (the latter measured in te...

journal_title：Epilepsy research

authors： Neligan A,Shorvon SD

更新日期：2011-01-01 00:00:00